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KMID : 0614020020170010028
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Journal of Pharmaceutical Sciences (C.N.U.)
2002 Volume.17 No. 1 p.28 ~ p.32
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Inhibitory Effects of Vietnamese Medicinal Plants on Monoamine Oxidase Activity
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Hung Vu-Manh
Minh Chau Van
Kiem Phan Van
Huong Dang Thi Lan
Nguyen Tien-Dat
Kim Young-Ho
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Abstract
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In vitro in screening test aiming to find monoamine oxidase (MAO) inhibitors from Vietnamese medicinal plants, the MeOH extracts of seventeen medicinal plants were tested for the inhibitory effects on monoamine oxidase activity. MAO was purified from mouse brain and its activity was determined by fluorospectrophotometer using kynuramine as a substrate. Five MeOH extracts of medicinal plants including Cnidium monnineri showed quite strong inhibitory effects at the concentration of 250 ㎍/㎖. Six MeOH extracts of herbs including Astragalus membranaceus showed moderate inhibitory effects on this enzyme. Seven medicinal plants which showed good inhibitory effects on MAO were fractionated with CH_2Cl_2, EtOAc, BuOH and H_2O, successively. They were investigated for the inhibitory effects on MAO.
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KEYWORD
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Screening study, Vietnamese medicinal plants, extraction and fractionation, monoamine oxidase inhibitory activity
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